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Contraindicated. CYP3A4 is to blame for the formation and elimination of cariprazine's Lively metabolites. The effect of CYP3A4 inducers on cariprazine publicity has not been evaluated as well as Web effect is unclear.pentobarbital will reduce the extent or effect of trazodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Mo